Weifeng Dong

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About

Weifeng Dong is a leading researcher in chemical biology and cancer therapeutics, with a primary focus on protein myristoylation and its role in B-cell malignancies. His most impactful work, "Targeting N-myristoylation for therapy of B-cell lymphomas" (2020, 64 citations), systematically investigates N-myristoyltransferases (NMTs) as anti-cancer targets, demonstrating that cancer cells exhibit elevated NMT expression and that pharmacological inhibition of this fatty acid modification disrupts membrane targeting and oncogenic signaling. This seminal study established a mechanistic framework for targeting protein lipidation in hematologic cancers, opening new avenues for precision therapy. Beyond this landmark paper, Dong’s contributions span the development of selective NMT inhibitors and the elucidation of myristoylation-dependent pathways in lymphoma pathogenesis. His work has been widely recognized for bridging fundamental biochemistry with translational oncology, earning citations across chemical biology, medicinal chemistry, and clinical cancer research communities. By validating NMTs as druggable vulnerabilities in B-cell lymphomas, Dong has positioned himself at the forefront of targeting post-translational modifications for cancer treatment, offering a compelling alternative to conventional chemotherapy.