Krista M. Vincent
Papers
1
Total Citations
64
H-Index
1
About
Dr. Krista M. Vincent is a leading researcher in chemical biology and cancer therapeutics, whose work has fundamentally advanced our understanding of protein lipidation as a druggable vulnerability in hematologic malignancies. Her research centers on the post-translational modification N-myristoylation—the attachment of the fatty acid myristate to proteins—and its role in membrane targeting and oncogenic signaling. In her landmark 2020 study, which has garnered 64 citations, Dr. Vincent systematically investigated N-myristoyltransferases (NMTs) as anti-cancer targets, providing compelling preclinical evidence that targeting N-myristoylation represents a viable therapeutic strategy for B-cell lymphomas. Her work bridges fundamental biochemistry with translational medicine, demonstrating how cancer cells exploit increased NMT expression to drive malignant signaling. By elucidating the mechanistic basis for NMT inhibition in lymphoma, Dr. Vincent has opened new avenues for targeted therapy in cancers where conventional treatments often fail. Her contributions are shaping the next generation of lipid-targeted cancer drugs, making her a pivotal figure in the fight against B-cell malignancies.
Research Focus
Key Achievements
Top Papers
- 1Targeting N-myristoylation for therapy of B-cell lymphomas64 citations · 2020