Tilmann Weber

Novo Nordisk Foundation, Technical University of Denmark

Papers

Total Citations

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About

Tilmann Weber is a leading figure in synthetic biology and natural product discovery, with a primary focus on *Streptomyces* bacteria—prolific producers of antibiotics and other bioactive compounds. His research centers on developing innovative genetic engineering tools to unlock the vast biosynthetic potential of these organisms. A major contribution is the development of "ActinoMation," a literate programming approach for medium-throughput robotic conjugation of *Streptomyces* spp., which streamlines the genetic manipulation of these industrially important bacteria. Weber also pioneered the use of natural transformation for automated cloning, creating affordable, high-throughput platforms that bypass traditional *E. coli*-based bottlenecks. His work has garnered over 1,500 citations, reflecting its significant impact on the field. Notably, his 2020 paper on automating cloning by natural transformation (26 citations) and his 2024 ActinoMation study (2 citations) exemplify his commitment to democratizing synthetic biology tools. Weber's achievements include leading international collaborations and contributing to the discovery of novel natural products, making him a key resource for researchers seeking to engineer microbial cell factories for drug discovery and sustainable biotechnology.