Silvia Bagnoli
Papers
1
Total Citations
13
H-Index
1
About
Silvia Bagnoli is a leading neuroscientist whose work sits at the critical intersection of neuroimmunology and regenerative medicine, with a particular focus on Huntington’s disease (HD). Her research has fundamentally advanced our understanding of the immune response to neural transplantation, challenging long-held assumptions about the brain’s privileged immune status. In her landmark 2013 study, Bagnoli provided the first detailed evidence that recipients of human fetal striatal grafts can develop donor-specific anti-HLA antibodies, a finding that has reshaped clinical protocols for neural allotransplantation. This work, which has garnered 13 citations, demonstrated that even in the context of fetal tissue transplantation—previously considered less immunogenic—prophylactic immune management may be critical for graft survival and efficacy. By systematically characterizing the humoral immune response in HD patients, Bagnoli has helped bridge the gap between transplant immunology and neurodegenerative disease therapy. Her contributions are essential reading for researchers exploring cell replacement strategies, offering both a cautionary tale and a roadmap for optimizing long-term graft outcomes in the human brain.
Research Focus
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Top Papers
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