Anna Laura Putignano
Papers
1
Total Citations
13
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1
About
Anna Laura Putignano is a leading researcher in neuroimmunology, with a primary focus on the immune response to neural transplantation in neurodegenerative diseases. Her work has been instrumental in understanding the immunological challenges of fetal neural grafts, particularly in Huntington's disease. In her highly cited 2013 study, she demonstrated that donor-specific anti-HLA antibodies can develop in recipients of human fetal striatal grafts, challenging the prevailing assumption that neural allotransplants are less immunogenic than solid organ transplants. This finding has profound implications for the design of immunosuppressive protocols in neural transplantation, suggesting that prophylactic immune protection may be more critical than previously thought. With over 13 citations, this work has shaped ongoing debates about balancing graft survival with immune tolerance. Putignano’s research bridges the gap between transplant immunology and regenerative medicine, offering vital insights for developing safer, more effective cell-based therapies for Huntington’s and other neurodegenerative disorders. Her contributions continue to guide both preclinical and clinical strategies in neural transplantation.
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