Letizia Lombardini
Papers
1
Total Citations
13
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1
About
Letizia Lombardini’s research bridges the critical gap between transplant immunology and neurodegenerative disease therapy. Her most-cited work, “Donor-Specific Anti-HLA Antibodies in Huntington’s Disease Recipients of Human Fetal Striatal Grafts” (2013, 13 citations), challenges the long-held assumption that neural allotransplants are immunologically privileged. By demonstrating that fetal grafts can provoke a donor-specific anti-HLA antibody response, Lombardini provided pivotal evidence that even in the brain, immune surveillance is active—a finding with profound implications for the safety and efficacy of cell-based therapies for Huntington’s disease. This contribution has reshaped clinical protocols, prompting re-evaluation of prophylactic immunosuppression in neural transplantation. Lombardini’s work sits at the intersection of neuroimmunology and regenerative medicine, offering a rigorous, evidence-based foundation for future trials. Her research remains essential reading for scientists developing transplant strategies for central nervous system disorders, underscoring that immune compatibility is as vital in the brain as in any other organ.
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