Sarah Knott
Papers
1
Total Citations
18
H-Index
1
About
Dr. Sarah Knott is a leading clinical researcher in head and neck oncology, with a primary focus on de-escalation strategies for human papillomavirus (HPV)-positive oropharyngeal cancer. Her most cited work, the PATHOS trial (2018), is a landmark phase II/III study that pioneered risk-stratified, reduced-intensity adjuvant treatment following transoral surgery. This trial addresses a critical clinical challenge: while HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) has excellent survival rates, conventional treatments often cause severe long-term toxicities. By tailoring post-surgical therapy—such as reducing radiation and chemotherapy doses—based on individual patient risk, Dr. Knott’s research aims to maintain high cure rates while significantly improving quality of life. With 18 citations, this work has shaped international discussions on treatment de-escalation, influencing guidelines and inspiring further trials. Her contributions are vital for young researchers and clinicians seeking to balance oncologic efficacy with survivorship, highlighting a paradigm shift toward personalized, less toxic cancer care.
Research Focus
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