Paul Leo
Papers
1
Total Citations
51
H-Index
1
About
Paul Leo is a leading figure in functional genomics, with a primary focus on high-throughput screening technologies and the systematic analysis of the human genome. His most impactful work centers on the development of scalable platforms for gene overexpression studies, exemplified by his landmark 2011 paper, "A High-Throughput Platform for Lentiviral Overexpression Screening of the Human ORFeome," which has garnered 51 citations. In this study, Leo and his team engineered a robust pipeline to transfer protein-coding open reading frames from the Mammalian Gene Collection into lentiviral vectors, enabling the functional interrogation of thousands of human genes in parallel. This innovation addressed a critical bottleneck in genomics—the need for efficient, reproducible methods to link genes to their biological roles. By providing a standardized, high-throughput tool for overexpression screening, Leo’s work has empowered researchers to systematically explore gene function in disease contexts, drug target discovery, and cellular pathway mapping. His contributions have accelerated the transition from genome sequencing to functional understanding, making him a key architect of modern functional genomics and a vital resource for the scientific community.
Research Focus
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Top Papers
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