Patrick Barton
Papers
1
Total Citations
38
H-Index
1
About
Dr. Patrick Barton has made significant contributions to the field of pharmaceutical sciences, with a primary focus on improving the accuracy and efficiency of physicochemical property measurements for drug discovery. His most cited work, "A Highly Automated Assay for Determining the Aqueous Equilibrium Solubility of Drug Discovery Compounds" (2011), addresses a critical bottleneck in early-stage drug development. This paper, with 38 citations, introduces a novel high-throughput method that provides true thermodynamic solubility data, moving beyond the less reliable kinetic estimates commonly used in the industry. By automating the equilibrium solubility assay, Dr. Barton’s research enables more accurate predictions of a compound’s behavior in biological systems, directly impacting the selection of viable drug candidates. His work is particularly valued for bridging the gap between rapid screening and the rigorous thermodynamic measurements required for regulatory and formulation studies. Dr. Barton’s contributions are essential for researchers seeking to improve the success rate of drug development pipelines, and his automated assay remains a benchmark for solubility assessment in pharmaceutical research.
Research Focus
Key Achievements
Top Papers
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