Solubility

Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success

Ryan Choi, Angela Kelley, D.J. Leibly, Stephen N. Hewitt, Alberto J. Napuli, Wesley Van Voorhis

Citations: 103 • 2011

Rigid Tightly Packed Amino Acid Crystals as Functional Supramolecular Materials

Wei Ji, Bin Xue, Zohar A. Arnon, Hui Yuan, Santu Bera, Qi Li, Dor Zaguri, Nicholas P. Reynolds, Hui Li, Yu Chen, Sharon Gilead, Sigal Rencus‐Lazar, Junbai Li, Rusen Yang, Yi Cao, Ehud Gazit

Citations: 95 • 2019

Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility

Karen A. Dehring, Heather Workman, Keith Miller, Arun K. Mandagere, Salwa K. Poole

Citations: 77 • 2004

Automated solubility screening platform using computer vision

Parisa Shiri, Veronica Lai, Tara Zepel, Daniel J. Griffin, Jonathan Reifman, Sean Clark, Shad Grunert, Lars P. E. Yunker, Sebastian Steiner, Henry Situ, Fan Yang, Paloma L. Prieto, Jason E. Hein

Citations: 74 • 2021

Combination of Pluronic/Vitamin E TPGS as a potential inhibitor of drug precipitation

Weiguo Dai, Dong Liang, Shu Li, Zhengyu Deng

Citations: 65 • 2007

An integrated high-throughput robotic platform and active learning approach for accelerated discovery of optimal electrolyte formulations

Juran Noh, Hieu A. Doan, Heather Job, Lily A. Robertson, Lu Zhang, Rajeev S. Assary, Karl T. Mueller, Vijayakumar Murugesan, Yangang Liang

Citations: 64 • 2024

Development of a partially automated solubility screening (PASS) assay for early drug development

Jochem Alsenz, Eva Meister, Elisabeth Haenel

Citations: 63 • 2007

An Automated Screening Assay for Determination of Aqueous Equilibrium Solubility Enabling SPR Study During Drug Lead Optimization

Helming Tan, David Semin, Maggie Wacker, Janet Cheetham

Citations: 52 • 2005

Enhanced Bioavailability of a Poorly Water-Soluble Weakly Basic Compound Using a Combination Approach of Solubilization Agents and Precipitation Inhibitors: A Case Study

Shu Li, Crystal Pollock‐Dove, Dong Liang, Jing Chen, Abla A. Creasey, Weiguo Dai

Citations: 41 • 2012

Influence of binding pH and protein solubility on the dynamic binding capacity in hydrophobic interaction chromatography

Pascal Baumann, Kai Baumgartner, Jürgen Hubbuch

Citations: 38 • 2015

A Highly Automated Assay for Determining the Aqueous Equilibrium Solubility of Drug Discovery Compounds

Mark C. Wenlock, Rupert P. Austin, Tim Potter, Patrick Barton

Citations: 38 • 2011

Deep-Sea Field Test of the CH₄ Hydrate to CO₂ Hydrate Spontaneous Conversion Hypothesis

Peter G. Brewer, Edward T. Peltzer, P. M. Walz, Elizabeth K. Coward, Laura A. Stern, S. H. Kirby, John Pinkston

Citations: 36 • 2014

Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments

Cecilie Maria Madsen, Kung‐I Feng, Andrew Leithead, Nicole Canfield, Søren Astrup Jørgensen, Anette Müllertz, Thomas Rades

Citations: 36 • 2017

Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material

Weiguo Dai, Dong Liang, Shu Li, Crystal Pollock‐Dove, Jing Chen, P. Mansky, Gary Eichenbaum

Citations: 35 • 2006

Integration of a rapid automated solubility classification into early validation of hits obtained by high throughput screening

Thilo A. Fligge, Andrea Schuler

Citations: 34 • 2006

Comparative Drug Solubility Studies Using Shake-Flask Versus a Laser-Based Robotic Method

Elaheh Rahimpour, Milad Moradi, Atefeh Sheikhi-Sovari, Homa Rezaei, Hadis Rezaei, Vahid Jouyban‐Gharamaleki, Martin Kuentz, Abolghasem Jouyban

Citations: 29 • 2023

Integrated System Built for Small-Molecule Semiconductors via High-Throughput Approaches

Jianchang Wu, Jiyun Zhang, Manman Hu, Patrick Reiser, Luca Torresi, Pascal Friederich, Leopold Lahn, Olga Kasian, Dirk M. Guldi, M. Eugenia Pérez‐Ojeda, Anastasia Barabash, Juan S. Rocha‐Ortiz, Yicheng Zhao, Zhiqiang Xie, Junsheng Luo, Yunuo Wang, Sang Il Seok, Jens Hauch, Christoph J. Brabec

Citations: 29 • 2023

A novel method to evaluate protein solubility using a high throughput screening approach

Matthias Wiendahl, Christiane Völker, Ilka Husemann, Janus Krarup, Arne Staby, Stephan Scholl, Jürgen Hubbuch

Citations: 28 • 2009

An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement

Marc Oeller, Pietro Sormanni, Michele Vendruscolo

Citations: 28 • 2021

Crystallographic Fragment Screening

John Badger

Citations: 26 • 2011