Nivedita Sengupta
Papers
1
Total Citations
28
H-Index
1
About
Dr. Nivedita Sengupta is a leading cell biologist whose research focuses on the molecular mechanisms of lipid signaling, with a particular emphasis on the regulation and function of phosphatidylinositol 4-kinases (PI4Ks). Her major contributions center on understanding how these enzymes generate the critical signaling lipid PI4P at distinct membrane compartments to control lipid transfer, membrane trafficking, and cellular homeostasis. In her landmark 2019 study, Dr. Sengupta spearheaded a large-scale, high-throughput chemical screen to identify specific inhibitors of phosphatidylinositol 4-kinase type II alpha (PI4KIIα), a key enzyme involved in generating PI4P at endosomal and Golgi membranes. This work, which has garnered 28 citations, provided the first selective chemical tools to dissect the unique roles of PI4KIIα, paving the way for future studies on its involvement in disease, including cancer and viral replication. Her research has been instrumental in establishing PI4P as a master regulator of lipid exchange at membrane contact sites, offering new insights into fundamental cell biology and potential therapeutic targets.
Research Focus
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Top Papers
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