David J. Flanders
Papers
1
Total Citations
47
H-Index
1
About
David J. Flanders has made significant contributions to stem cell biology and neurotoxicology, with a focus on developing scalable, reproducible platforms for studying human neural development and disease. His most cited work, "Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell–Derived Neuroepithelial-like Stem Cells" (2012, 47 citations), pioneered the integration of automated culture systems with medium-throughput screening to assess how chemical compounds affect the growth and survival of neural stem cells derived from human induced pluripotent stem cells (iPSCs). This approach enabled more efficient, high-content analysis of neurodevelopmental toxicity and drug effects, bridging the gap between basic stem cell research and translational applications. Flanders’ work has been instrumental in advancing methods for standardized neural cell production and chemical safety testing, impacting fields from regenerative medicine to environmental health. His research underscores the potential of combining stem cell technology with automation to accelerate discovery, and his 2012 paper remains a foundational reference for scientists developing high-throughput neural screening platforms.
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