Daniel Margolis

About

Daniel Margolis is a leading researcher at the intersection of prostate cancer imaging and surgical planning, whose work has fundamentally reshaped how clinicians diagnose and treat this disease. His primary contributions lie in advancing multiparametric magnetic resonance imaging (MRI) and developing novel biopsy techniques to improve cancer detection and treatment precision. Margolis is best known for demonstrating the critical role of MRI in surgical decision-making, particularly for robotic-assisted laparoscopic prostatectomy (RALP). His seminal 2012 study (138 citations) showed how preoperative endorectal coil MR imaging directly influences the decision to preserve neurovascular bundles, a key factor in maintaining post-surgical quality of life. He further pioneered the use of time-driven activity-based costing (TDABC) to analyze the economic realities of treating low-risk prostate cancer (144 citations), providing vital data for healthcare policy. Margolis also advanced the field of radiogenomics, correlating multiparametric MR imaging with DNA whole-exome sequencing to map prostate microenvironments. His work on MRI-ultrasound fusion–guided biopsy (104 citations) and diffusion tensor tractography for mapping periprostatic fibers has set new standards for targeted diagnostics. Through these innovations, Margolis has bridged radiology, urology, and oncology, offering patients more personalized, less invasive care.

Research Focus

Key Achievements

Top Papers

1. 1
   Utilizing time‐driven activity‐based costing to understand the short‐ and long‐term costs of treating localized, low‐risk prostate cancer

   144 citations · 2015
2. 2
   Use of MR Imaging to Determine Preservation of the Neurovascular Bundles at Robotic-assisted Laparoscopic Prostatectomy

   138 citations · 2012
3. 3
   Target detection: Magnetic resonance imaging-ultrasound fusion–guided prostate biopsy

   104 citations · 2013
4. 4
   Radical prostatectomy: value of prostate MRI in surgical planning

   43 citations · 2011
5. 5
   Diffusion Tensor Magnetic Resonance Tractography of the Prostate: Feasibility for Mapping Periprostatic Fibers

   39 citations · 2012
6. 6
   Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR Imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma

   33 citations · 2017
7. 7
   Fine-tuning robot-assisted radical prostatectomy planning with MRI

   12 citations · 2011
8. 8
   IDEAL Stage 2a experience with in-office, transperineal MRI/ultrasound software fusion targeted prostate biopsy

   5 citations · 2019

Key Collaborators

Contact & Links