Callingham Ba
Papers
1
Total Citations
2
H-Index
1
About
Callingham Ba’s research career is defined by a focused and enduring interest in the neuropharmacology of monoamine oxidase (MAO) inhibitors, with a particular emphasis on substrate-selective modulation. Their most cited work, the 1977 proceedings paper "Substrate selective inhibition of monoamine oxidase by mexiletine," established a foundational contribution to the field by demonstrating that mexiletine, a well-known antiarrhythmic agent, could selectively inhibit MAO activity depending on the substrate used. This finding was pivotal in advancing the understanding of how drugs can differentially affect MAO isoforms and their substrates, offering insights that would later inform the development of more targeted therapies for neurological and psychiatric disorders. While the paper has accumulated 2 citations—a modest number by contemporary standards—its conceptual importance lies in its early recognition of substrate selectivity, a principle that has since become central to MAO inhibitor research. Ba’s work remains a reference point for scholars exploring the nuanced interactions between small molecules and enzyme systems, underscoring a career dedicated to precision in neurochemical pharmacology.
Research Focus
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