Alberto Smith

King's College London, Norwich University

Papers

Total Citations

496

H-Index

About

Alberto Smith is a leading investigator in vascular biology, with a primary focus on the molecular mechanisms underlying abdominal aortic aneurysms (AAA) and atherosclerosis. His work has fundamentally advanced our understanding of how the extracellular matrix (ECM) remodels in diseased arteries. In his landmark 2011 study, "Extracellular Matrix Composition and Remodeling in Human Abdominal Aortic Aneurysms," Smith employed a cutting-edge proteomics approach to move beyond the well-known processes of elastolysis and collagenolysis, revealing a far more complex landscape of ECM protein changes. This highly influential paper has garnered 286 citations, establishing a new paradigm for AAA research. In a second seminal contribution, "Comparative Lipidomics Profiling of Human Atherosclerotic Plaques" (210 citations), he pioneered the use of chip-based nanoelectrospray mass spectrometry to perform a systematic, detailed lipid analysis directly from tissue sections. This work provided an unprecedented molecular fingerprint of plaque lipids, offering critical insights into the composition of atherosclerotic lesions. Through these innovative, high-resolution molecular profiling studies, Smith has provided the field with essential new tools and foundational datasets, profoundly shaping our understanding of vascular disease pathogenesis.