High-content screening

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

Stefan Czerniecki, Nelly M. Cruz, Jennifer L. Harder, Rajasree Menon, James Annis, Edgar A. Otto, Ramila E. Gulieva, Laura Islas, Yong Kyun Kim, Linh M. Tran, Timothy J. Martins, Jeffrey W. Pippin, Hongxia Fu, Matthias Kretzler, Stuart J. Shankland, Jonathan Himmelfarb, Randall T. Moon, Neal Paragas, Benjamin Freedman

Citations: 461 • 2018

Novel fluorescent proteins for high-content screening

Michael W. Wolff, Joerg Wiedenmann, G. Ulrich Nienhaus, Martin J. Valler, Ralf Heilker

Citations: 72 • 2006

Homogeneous Cell- and Bead-Based Assays for High Throughput Screening Using Fluorometric Microvolume Assay Technology

Sheri Miraglia, Elana Swartzman, Julia Mellentin-Michelotti, Lolita Evangelista, Christopher J. Smith, Iwan Gunawan, Kenton L. Lohman, E. Matilda Goldberg, Bala S. Manian, Pau-Miau Yuan

Citations: 67 • 1999

Evolution and impact of high content imaging

Gregory P. Way, Heba Sailem, Steven Shave, Richard Kasprowicz, Neil O. Carragher

Citations: 61 • 2023

Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release

Jonathan Shpigelman, Fitzgerald S. Lao, Shiyin Yao, Chenyang Li, Tetsuya Saito, Fumi Sato-Kaneko, John P. Nolan, Nikunj M. Shukla, Minya Pu, Karen Messer, Howard B. Cottam, Dennis A. Carson, Maripat Corr, Tomoko Hayashi

Citations: 58 • 2021

Unsupervised Fluorescence Lifetime Imaging Microscopy for High Content and High Throughput Screening

Alessandro Esposito, Christoph P. Dohm, Mathias Bähr, Fred S. Wouters

Citations: 57 • 2007

Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research

Dean G. Brown, Heike J. Wobst

Citations: 49 • 2019

Automated 3D light-sheet screening with high spatiotemporal resolution reveals mitotic phenotypes

Björn Eismann, Teresa G. Krieger, Jürgen Beneke, Ruben Bulkescher, Lukas Adam, Holger Erfle, Carl Herrmann, Roland Eils, Christian Conrad

Citations: 40 • 2020

Step-by-step guide to building an inexpensive 3D printed motorized positioning stage for automated high-content screening microscopy

Dominik Schneidereit, Larissa Kraus, Jochen C. Meier, Oliver Friedrich, Daniel F. Gilbert

Citations: 39 • 2016

A computational platform for robotized fluorescence microscopy (I): High‐content image‐based cell‐cycle analysis

Laura Furia, Pier Giuseppe Pelicci, Mario Faretta

Citations: 37 • 2013

Moving to the Core: Spatiotemporal Analysis of Forkhead Box O (<scp>FOXO</scp>) and Nuclear Factor‐<scp>κB</scp> (<scp>NF‐κB</scp>) Nuclear Translocation

Fabian Zanella, Nuno R. dos Santos, Wolfgang Link

Citations: 35 • 2012

A Pharmaceutical Company User's Perspective on the Potential of High Content Screening in Drug Discovery

Ann F. Hoffman, Ralph Garippa

Citations: 33 • 2006

An Automated High-Content Assay for Tumor Cell Migration through 3-Dimensional Matrices

Victoria Echeverria, Ivar Meyvantsson, Allyson Skoien, Tracy J Worzella, Casey Lamers, Steven Hayes

Citations: 24 • 2010

Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation

Joan Savall, Eric Tatt Wei Ho, Cheng Huang, Jessica R. Maxey, Mark J. Schnitzer

Citations: 23 • 2015

Development of an automated 3D high content cell screening platform for organoid phenotyping

Suleyman B. Bozal, Greg Sjogren, António P. Costa, Shannon Roberts, Dylan Baker, Paul Gabriel, Benjamin T. Ristau, Michael L. Samuels, William F. Flynn, P. R. H. Robson, Elise T. Courtois

Citations: 18 • 2024

Advances and challenges in high-throughput microscopy for live-cell subcellular imaging

Martin Oheim

Citations: 18 • 2011

Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery

Winston Chiu, Joost Schepers, Thibault Francken, Laura Vangeel, Kayvan Abbasi, Dirk Jochmans, Steven De Jonghe, Hendrik Jan Thibaut, Volker Thiel, Johan Neyts, Manon Laporte, Pieter Leyssen

Citations: 14 • 2022

Cellular nucleus image-based smarter microscope system for single cell analysis

Wentao Wang, Lin Yang, Hang Sun, Xiaohong Peng, Junjie Yuan, Wenhao Zhong, Jinqi Chen, Xin He, Lingzhi Ye, Yi Zeng, Zhifan Gao, Yunhui Li, Xiangmeng Qu

Citations: 12 • 2024

Automated High-Throughput Flow Cytometry for High-Content Screening in Antibody Development

Yana Wang, Tomoki Yoshihara, Samson G. King, Tinh Le, Patrick Leroy, Xiansi Zhao, Ching Kit Chan, Zhonghua Yan, Saurabh Menon

Citations: 11 • 2018

Human Pluripotent Stem Cells: The Development of High-Content Screening Strategies

Sean P. Sherman, Jackelyn A. Alva, Kaushali Thakore-Shah, April D. Pyle

Citations: 11 • 2011