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Dr. Zhong-Ke Yao is pioneering the integration of fluorescence-guided surgery with advanced molecular imaging, with a primary focus on intraoperative nerve identification. Their most notable contribution is the development and clinical characterization of Rizedisben, a myelin-binding fluorophore that fluoresces in the blue light spectrum (370–425 nm) to enhance real-time visualization of nerves during minimally invasive procedures. This work addresses a critical challenge in surgery—avoiding nerve damage—by providing surgeons with a reliable optical contrast agent. In their landmark 2025 study, Dr. Yao systematically determined the optimal safe and effective dosing parameters for Rizedisben, laying the groundwork for its translational application. With 4 citations already accrued, this foundational paper is poised to influence a growing field. Dr. Yao’s research sits at the intersection of biomedical optics, surgical oncology, and neuroprotection, offering a tangible path toward safer, more precise operations. Their work is especially relevant for students and researchers interested in theranostics, image-guided interventions, and the clinical translation of novel fluorophores.