Thomas R. Miller
Papers
1
Total Citations
7
H-Index
1
About
Thomas R. Miller is a distinguished pharmacologist whose work has significantly advanced the understanding of G protein-coupled receptor (GPCR) signaling, particularly within the histamine H₃ receptor system. His key research areas encompass receptor pharmacology, functional assay development, and the characterization of ligand-receptor interactions. Miller’s most notable contribution is the establishment of a robust, high-capacity [³⁵S]GTPγS binding assay, a seminal methodological advancement that enables precise determination of antagonist and inverse agonist parameters for histamine H₃ receptor ligands. This work, cited 7 times, provides a reliable functional platform for screening novel compounds, bridging the gap between binding affinity and functional efficacy. By refining this assay, Miller has empowered researchers to dissect complex pharmacological behaviors, including inverse agonism, which is critical for developing therapeutic agents targeting neurological and inflammatory conditions. His contributions have laid a foundational tool for drug discovery, influencing subsequent studies on GPCR signaling and histamine receptor pharmacology. Miller’s meticulous approach and technical innovation continue to inspire students and researchers in the field of receptor biology and assay development.
Research Focus
Key Achievements
Top Papers
- 1