Arlene M. Manelli
Papers
1
Total Citations
7
H-Index
1
About
Arlene M. Manelli is a pharmacologist whose work has advanced the functional characterization of G protein-coupled receptors (GPCRs), with a particular focus on the histamine H₃ receptor. Her key research centers on developing and validating high-throughput binding assays to probe receptor pharmacology, especially for neurological and inflammatory targets. Her most notable contribution is the establishment of a robust, high-capacity [³⁵S]GTPγS binding assay for the histamine H₃ receptor, a critical tool for determining antagonist and inverse agonist parameters of novel ligands. This work, published in 2008 and cited 7 times, provided a reliable functional assay that enabled more precise screening of H₃ receptor modulators, which are relevant for treating cognitive and sleep disorders. By refining assay conditions to maximize signal-to-noise ratios and throughput, Manelli’s methodology has supported drug discovery efforts and deepened understanding of constitutive receptor activity. Her technical expertise in radioligand binding and GPCR signaling continues to inform the development of therapeutic ligands, making her contributions valuable to researchers in neuropharmacology and medicinal chemistry.
Research Focus
Key Achievements
Top Papers
- 1