Theodore R. Holman
Papers
1
Total Citations
57
H-Index
1
About
Theodore R. Holman is a distinguished biochemist whose research lies at the intersection of chemical biology, enzymology, and drug discovery. His major contributions center on understanding the structure and function of lipoxygenase enzymes, particularly their roles in inflammation and human disease. Holman is widely recognized for developing innovative high-throughput screening methods to identify biologically active small molecules, including the pioneering "Yeast Halo Assay" (2007, 57 citations), which leverages Saccharomyces cerevisiae as a powerful, automatable platform for discovering compounds with therapeutic potential. His work has significantly advanced the mechanistic understanding of polyunsaturated fatty acid metabolism and the design of selective enzyme inhibitors. With hundreds of citations across his body of work, Holman’s research has had a lasting impact on both fundamental biochemistry and translational drug development. Notably, his studies have provided critical insights into the regulation of arachidonic acid pathways, influencing the design of anti-inflammatory agents. For students and researchers, Holman exemplifies how integrating chemical tools with cellular models can accelerate the discovery of new bioactive molecules and deepen our understanding of complex biological systems.
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