Kathleen M. Krueger
Papers
1
Total Citations
7
H-Index
1
About
Kathleen M. Krueger is a distinguished pharmacologist whose research centers on G protein-coupled receptor (GPCR) signaling and the development of robust functional assays for drug discovery. Her most significant contribution lies in establishing a high-capacity [³⁵S]GTPγS binding assay for the histamine H₃ receptor, a critical GPCR target for neurological and metabolic disorders. This work, published in 2008, has garnered 7 citations and provides a reliable, high-throughput method for determining both antagonist and inverse agonist pharmacological parameters of novel H₃ ligands. By enabling precise characterization of ligand efficacy at the recombinant human H₃ receptor, Krueger’s assay has become a foundational tool for researchers exploring histamine signaling and developing therapeutic compounds. Her methodological rigor and focus on assay optimization have advanced the understanding of receptor pharmacology, offering a scalable solution for screening potential drug candidates. Krueger’s contributions are particularly valuable for students and researchers in GPCR biology and drug development, as her work bridges the gap between basic receptor science and practical, high-throughput screening applications.
Research Focus
Key Achievements
Top Papers
- 1