John L. Baranowski
Papers
1
Total Citations
7
H-Index
1
About
John L. Baranowski is a pharmacologist whose work has advanced the functional characterization of G protein-coupled receptors (GPCRs), with a particular focus on the histamine H₃ receptor. His key research areas include receptor pharmacology, assay development, and the study of inverse agonism and antagonism in drug discovery. Baranowski’s most notable contribution is the development of a robust, high-capacity [³⁵S]GTPγS binding assay, which provided a reliable functional method for determining the pharmacological parameters of histamine H₃ receptor ligands. This work, published in 2008, has garnered 7 citations and remains a methodological reference for researchers investigating GPCR signaling and ligand efficacy. By enabling the precise characterization of both antagonists and inverse agonists, Baranowski’s assay has supported the screening of novel therapeutic compounds targeting the H₃ receptor, which is implicated in neurological and metabolic disorders. His contributions underscore the importance of rigorous functional assays in bridging the gap between ligand binding and therapeutic potential, making his work valuable for students and researchers in molecular pharmacology and drug development.
Research Focus
Key Achievements
Top Papers
- 1