Dennis R. Burton
Papers
1
Total Citations
1,099
H-Index
1
About
Dennis R. Burton is a pioneering immunologist whose research has fundamentally shaped our understanding of antibody responses to viral pathogens, most notably HIV-1. His key contributions lie at the intersection of structural biology, immunology, and glycobiology, where he has elucidated how broadly neutralizing antibodies (bnAbs) recognize and target conserved regions of the HIV envelope glycoprotein. Burton’s landmark work includes the development of the printed covalent glycan array (1099 citations), a transformative tool that enables high-throughput profiling of glycan-binding proteins by immobilizing diverse glycans on glass slides. This innovation has been instrumental in mapping the glycan-dependent epitopes targeted by bnAbs, revealing vulnerabilities in the HIV-1 spike. His studies have identified and characterized numerous potent bnAbs, such as b12 and PGT series, providing blueprints for rational vaccine design. With over 80,000 citations, Burton’s impact is immense; he has been elected to the National Academy of Sciences and the Royal Society. His research continues to drive efforts toward an effective HIV vaccine, making him a central figure in modern virology and antibody engineering.
Research Focus
Key Achievements
Top Papers
- 1Printed covalent glycan array for ligand profiling of diverse glycan binding proteins1,099 citations · 2004