Thomas Beneyton

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About

Thomas Beneyton is a leading figure in the development of droplet-based microfluidic platforms for ultra-high-throughput screening, with a particular focus on engineering microbial cell factories. His work masterfully combines microfluidics, synthetic biology, and directed evolution to accelerate the discovery and optimization of industrial enzymes. Beneyton’s most-cited study, "Droplet-Based Microfluidic High-Throughput Screening of Enzyme Mutant Libraries Secreted by Yarrowia lipolytica" (2021, 8 citations), exemplifies his core contribution: creating robust, miniaturized workflows that enable the rapid functional analysis of thousands of enzyme variants secreted by the non-conventional yeast *Yarrowia lipolytica*. This approach dramatically reduces the time and cost of screening compared to traditional plate-based methods, opening new avenues for engineering biocatalysts for applications in biofuels, bioplastics, and pharmaceuticals. His research has been instrumental in demonstrating how picoliter droplets can serve as artificial compartments for linking genotype to phenotype, a critical step for directed evolution. By pushing the boundaries of microfluidic technology, Beneyton is empowering researchers to explore vast sequence spaces and unlock the full potential of microbial enzymes for a sustainable bioeconomy.