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Teunis B. H. Geijtenbeek is a leading immunologist whose research has fundamentally reshaped our understanding of dendritic cell biology and viral pathogenesis. His work centers on the molecular mechanisms by which dendritic cells recognize pathogens, particularly through C-type lectin receptors, and how these interactions dictate immune activation versus viral subversion. Geijtenbeek is best known for identifying DC-SIGN as the primary receptor for HIV-1 on dendritic cells, a landmark discovery that revealed how the virus hijacks these immune sentinels to facilitate dissemination to T cells. This seminal contribution, alongside his later work on the signaling pathways of lectins like DC-SIGN and dectin-1, has been cited tens of thousands of times, establishing him as a pioneer in the field. His impact extends to the FANTOM5 consortium, where his contributions to mapping transcription initiation events across thousands of human and mouse samples (a paper with over 360 citations) have provided a critical resource for understanding gene regulation in immune cells. Through his elegant dissection of receptor signaling, Geijtenbeek has not only illuminated fundamental principles of innate immunity but also opened new avenues for therapeutic intervention in infectious diseases and inflammatory disorders.