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About

Dr. Ri-ichiroh Manabe is a leading computational biologist whose work has fundamentally advanced our understanding of gene regulation at the genomic scale. His primary research focuses on the analysis of transcription initiation and the functional annotation of the genome, with a particular emphasis on the FANTOM (Functional Annotation of the Mammalian Genome) consortium. Dr. Manabe’s most impactful contribution is his central role in the landmark FANTOM5 project, which produced the most comprehensive atlas of transcription start sites (TSSs) to date. His highly cited 2017 paper (over 360 citations) details the generation of Cap Analysis of Gene Expression (CAGE) profiles across nearly 3,000 human and mouse samples, mapping transcription initiation events at single base-pair resolution. This monumental work has provided an indispensable resource for the scientific community, enabling researchers to precisely define promoters and enhancers, and to understand how their usage varies across cell types and conditions. Through his meticulous data production and analysis, Dr. Manabe has helped illuminate the complex architecture of mammalian genomes, making him a pivotal figure in modern functional genomics.