Simon Koplev
Papers
1
Total Citations
447
H-Index
1
About
Simon Koplev is a computational biologist whose research centers on systems-level analysis of cellular signaling, network biology, and the integration of large-scale genomic datasets to understand human disease. He made a landmark contribution as a key participant in the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) Program, co-authoring its flagship 2017 paper, which has garnered over 447 citations. This work established a systematic framework for cataloging how human cells respond to diverse perturbations—drugs, genetic modifications, and disease states—by generating and integrating thousands of molecular signatures. Koplev’s efforts helped create a foundational public resource that enables researchers to predict drug mechanisms, identify new therapeutic targets, and map disease pathways. His broader impact lies in advancing network-based approaches to decode complex cellular behaviors, bridging high-throughput data with actionable biological insights. Through his contributions to LINCS, Koplev has empowered the biomedical community to move from descriptive genomics to predictive, mechanism-driven science, making his work essential reading for anyone interested in systems pharmacology and precision medicine.
Research Focus
Key Achievements
Top Papers
- 1