Sarah Gretzinger
Papers
2
Total Citations
31
H-Index
2
About
Sarah Gretzinger is a leading researcher in the field of bioprocess engineering, with a specific focus on advancing downstream processing for cell-based therapies. Her work is centered on the development of scalable, label-free separation technologies, most notably through the innovative use of aqueous two-phase systems (ATPS). Dr. Gretzinger’s major contribution lies in pioneering high-throughput methods to optimize ATPS for the purification of therapeutic cells, directly addressing a critical bottleneck in the translation of cell therapies from lab to clinic. Her most cited work, "High-throughput downstream process development for cell-based products using aqueous two-phase systems" (2016, 26 citations), established a foundational framework for this approach. She further refined this technology by systematically investigating how polymer molecular weight and tie-line length influence the separation resolution of different cell lines, as detailed in her 2017 study. By providing a cost-effective, scalable, and label-free alternative to traditional methods, Dr. Gretzinger’s research is instrumental in bridging the critical gap between basic research and the clinical-scale manufacturing of life-saving cell-based products.
Research Focus
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Top Papers
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