S. Vincent Wu
Papers
1
Total Citations
57
H-Index
1
About
S. Vincent Wu is a molecular pharmacologist whose research centers on the biophysics and pharmacology of G protein-coupled receptors (GPCRs), with a particular focus on how membrane lipids regulate receptor function. His most cited work, "Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol" (2011, 57 citations), demonstrates that membrane cholesterol selectively modulates the activity of CCK1R and CCK2R, revealing distinct lipid sensitivities among closely related GPCRs. This contribution has advanced understanding of how the lipid environment influences receptor signaling, with implications for drug design and diseases involving cholesterol dysregulation. Wu’s research has been recognized for its impact on the field of membrane receptor pharmacology, and his findings continue to inform studies on GPCR-lipid interactions. His work underscores the importance of the cellular membrane as an active participant in receptor function, offering new perspectives for therapeutic targeting of cholecystokinin receptors in gastrointestinal and neurological disorders.
Research Focus
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Top Papers
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