Kaleeckal G. Harikumar
Papers
1
Total Citations
57
H-Index
1
About
Dr. Kaleeckal G. Harikumar is a leading molecular pharmacologist whose research centers on the biophysics of G protein-coupled receptors (GPCRs), with a particular focus on how membrane lipids regulate receptor function. His major contributions have illuminated the differential sensitivity of cholecystokinin receptor subtypes to membrane cholesterol, demonstrating that while the type 1 receptor (CCK1R) is profoundly modulated by cholesterol levels, the type 2 receptor (CCK2R) is relatively resistant—a finding with significant implications for understanding receptor trafficking and signaling in disease states. His most-cited work, a 2011 study on this topic, has garnered 57 citations and is considered foundational in the field of lipid-GPCR interactions. Dr. Harikumar’s research bridges biophysics and pharmacology, offering mechanistic insights that could inform the development of targeted therapies for gastrointestinal and neurological disorders. His work continues to shape how scientists understand the dynamic interplay between membrane composition and receptor activity.
Research Focus
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Top Papers
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