Ross M. Potter
Papers
1
Total Citations
57
H-Index
1
About
Ross M. Potter is a leading investigator in the molecular pharmacology of G protein-coupled receptors (GPCRs), with a particular focus on the cholecystokinin (CCK) receptor system. His research has fundamentally advanced our understanding of how membrane lipids, especially cholesterol, modulate GPCR function. In his highly cited 2011 work (57 citations), Potter demonstrated that types 1 and 2 cholecystokinin receptors exhibit differential sensitivity to membrane cholesterol, revealing that CCK1R function is profoundly influenced by its lipid environment while CCK2R is comparatively resistant. This discovery has critical implications for drug design, suggesting that receptor-lipid interactions can be exploited for selective therapeutic targeting. Beyond this landmark study, Potter’s broader contributions include elucidating the structural and dynamic mechanisms by which cholesterol alters ligand binding and signal transduction in CCK receptors. His work has been instrumental in shifting the paradigm of GPCR biology from a purely protein-centric view to one that incorporates the regulatory role of the cell membrane. With a citation impact that continues to grow, Potter’s research is essential reading for anyone studying receptor pharmacology, membrane biophysics, or the development of drugs targeting gastrointestinal and neurological disorders.
Research Focus
Key Achievements
Top Papers
- 1