S. Manicka
Papers
1
Total Citations
5
H-Index
1
About
S. Manicka is a structural biologist whose research centers on the molecular mechanisms of bacterial pathogenesis and drug resistance, with a particular focus on the role of bacteriophage-mediated horizontal gene transfer. Her most cited work, the 2008 study on the crystal structure of YagE from *Escherichia coli K12*, provides critical insight into how lysogenic bacteriophages can incorporate foreign genetic material into bacterial genomes, potentially conferring novel forms of pathogenicity or antibiotic resistance. By elucidating the three-dimensional structure of this putative DHDPS-like protein, Manicka’s research has helped lay the groundwork for understanding the structural biology underlying bacterial evolution and the spread of virulence factors. Though her citation count is modest, this foundational study remains relevant for researchers investigating the molecular pathways that enable bacteria to acquire new traits, including drug resistance. Manicka’s work exemplifies the importance of structural analysis in decoding the hidden mechanisms of bacterial adaptation and highlights the ongoing threat posed by phage-mediated genetic exchange in clinical settings.
Research Focus
Key Achievements
Top Papers
- 1