Rotem Hazan
Papers
1
Total Citations
89
H-Index
1
About
Dr. Rotem Hazan is a molecular cell biologist whose research centers on the mechanisms of proteostasis and cellular adaptation to stress, with a particular focus on the regulation of the 26S proteasome. Her most cited work, "Formation and dissociation of proteasome storage granules are regulated by cytosolic pH" (2013, 89 citations), made a significant contribution by revealing that cytosolic pH acts as a key physiological signal governing the reversible assembly of proteasomes into storage granules during glucose depletion. Using a systematic robotic screening approach in yeast, she identified the molecular machinery that controls this dynamic process, providing fundamental insights into how cells safeguard their protein degradation machinery under nutrient stress. This discovery has broad implications for understanding cellular resilience and the pathophysiology of aging and neurodegenerative diseases where proteostasis is compromised. Dr. Hazan’s work elegantly bridges systems biology and cell physiology, establishing her as a leading voice in the study of proteasome regulation and stress-responsive cellular organization.
Research Focus
Key Achievements
Top Papers
- 1