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About

Quynh-Thu Le is a pioneering radiation oncologist whose groundbreaking research has fundamentally shaped the field of image-guided stereotactic radiosurgery, particularly in its application to extracranial sites. Working at the intersection of advanced imaging technology and precision radiation delivery, Le has been instrumental in demonstrating that frameless, noninvasive radiosurgical techniques — long established for brain tumors — could be safely and effectively extended to challenging anatomical targets including the spine, lung, and pancreas. Her most influential contributions center on establishing the technical feasibility of hypofractionated stereotactic radiosurgery for spinal lesions, including vascular malformations and metastatic tumors, with her landmark 2001 paper accumulating over 330 citations. Her early collaborative work on robotic image-guided systems for extracranial treatment, published in 2000, laid critical groundwork for what would become standard practice in modern radiation oncology, garnering nearly 230 combined citations across related publications. Le also conducted one of the earliest phase I clinical trials exploring stereotactic radiosurgery for lung tumors, earning over 310 citations and helping establish dose parameters that informed subsequent clinical protocols worldwide. Her body of work reflects a sustained commitment to expanding the boundaries of precision radiotherapy, improving outcomes for patients with previously difficult-to-treat lesions.