Ognjan Apostolov
Papers
1
Total Citations
42
H-Index
1
About
Ognjan Apostolov’s research centers on the molecular mechanisms of neurotrophin signaling, with a particular focus on the Trk receptor family and its role in neuronal survival, differentiation, and disease. His most cited work, a 2005 study employing two-dimensional fluorescence difference gel electrophoresis and mass spectrometry, provided the first dynamic proteome-wide map of changes triggered by ligand activation of TrkA and TrkB receptors. By identifying novel protein targets downstream of NGF and BDNF stimulation, Apostolov’s research illuminated how these pathways govern critical neuronal processes—from growth to apoptosis—and highlighted the prognostic significance of Trk receptor expression in cancers. With 42 citations, this foundational study remains a key reference for researchers exploring neurotrophin signaling networks and their therapeutic implications. Apostolov’s contributions have advanced our understanding of how receptor tyrosine kinases orchestrate cellular responses, bridging proteomics and neurobiology. His work continues to inform investigations into neurodegenerative diseases and cancer, where Trk dysregulation plays a pivotal role.
Research Focus
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Top Papers
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