Barbara Sitek
Papers
1
Total Citations
42
H-Index
1
About
Barbara Sitek is a leading figure in functional proteomics and neurobiology, whose work has fundamentally advanced our understanding of how cellular signaling drives disease. Her research centers on the dynamic interplay between protein expression and receptor activation, with a particular focus on neurotrophin signaling pathways. In her seminal 2005 study, Sitek pioneered the use of two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with mass spectrometry to map the proteomic landscape triggered by ligand activation of Trk-receptors. This work, which has garnered over 40 citations, provided the first comprehensive snapshot of how nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) orchestrate survival, differentiation, and apoptosis in neurons by remodeling the entire proteome. By identifying specific protein changes downstream of TrkA and TrkB—receptors that are critical prognostic markers in various cancers—Sitek’s contributions have bridged basic neurobiology with translational oncology. Her methodological innovations continue to inspire researchers exploring how dynamic protein networks govern cell fate, making her a pivotal voice in the quest to decode the molecular basis of neurological and malignant diseases.
Research Focus
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Top Papers
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