Noriko Sakurai
Papers
1
Total Citations
7
H-Index
1
About
Dr. Noriko Sakurai is a leading figure in genetic toxicology, best known for pioneering high-throughput genotoxicity screening methodologies. Her seminal work, "Improvement and Evaluation of High Throughput Fluctuation Ames Test Using 384-well Plate with Salmonella typhimurium TA100 and TA98," has garnered 7 citations and stands as a cornerstone in the field. This research addressed a critical bottleneck in drug discovery—the need for rapid, miniaturized assays compatible with combinatorial chemistry and robotics. By adapting the traditional Ames test to a 384-well plate format, Dr. Sakurai enabled the screening of thousands of compounds with minimal sample volume, dramatically accelerating early-stage safety assessments. Her contributions have been instrumental in shifting genotoxicity testing from labor-intensive, low-throughput methods to efficient, automated systems. This work not only enhanced the predictive power of mutagenicity screening but also reduced animal testing requirements, aligning with modern ethical standards. Dr. Sakurai’s innovations continue to influence pharmaceutical and environmental toxicology, providing researchers with robust tools to identify hazardous compounds swiftly and reliably.
Research Focus
Key Achievements
Top Papers
- 1