Miles D. Houslay
Papers
1
Total Citations
72
H-Index
1
About
Miles D. Houslay is a leading figure in cell signaling, with a particular focus on the molecular mechanisms by which scaffolding proteins coordinate complex signaling networks. His research has profoundly advanced our understanding of how cells integrate signals from growth factors and adhesion molecules to control proliferation and migration. A major contribution is his work on the scaffolding protein RACK1, where he demonstrated that insulin-like growth factor-I (IGF-I) orchestrates a competitive, mutually exclusive binding of PP2A and β1 integrin to RACK1. By identifying Tyrosine 302 as the critical switch point for this interaction, his 2008 study (72 citations) provided a mechanistic basis for how IGF-I receptor signaling is integrated with adhesion pathways, a process essential for tumor cell behavior. This foundational work has significant implications for understanding cancer progression and identifying new therapeutic targets. Houslay’s research is characterized by its elegant dissection of protein-protein interactions, revealing how dynamic competition for binding sites on scaffolds like RACK1 can dictate cellular outcomes.
Research Focus
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Top Papers
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