George S. Baillie
Papers
1
Total Citations
72
H-Index
1
About
George S. Baillie is a leading figure in cell signaling, with a particular focus on the molecular mechanisms that govern cancer cell behavior. His research centers on the intricate interplay between scaffolding proteins and signaling enzymes, especially how these interactions drive tumor cell proliferation and migration. A major contribution is his work on RACK1, a scaffolding protein that integrates signals from growth factor receptors and adhesion molecules. His most cited paper, from 2008, demonstrated that insulin-like growth factor-I (IGF-I) controls a competitive binding event between PP2A and β1 integrin at a specific tyrosine residue (Tyrosine 302) on RACK1. This discovery revealed a critical switch that coordinates IGF-I receptor and adhesion signaling, directly impacting tumor cell growth and movement. With 72 citations, this work has provided a foundational understanding of how signaling specificity is achieved at the molecular level. Baillie’s research has profound implications for developing targeted cancer therapies that disrupt these aberrant signaling pathways, marking him as a key contributor to the field of signal transduction and oncology.
Research Focus
Key Achievements
Top Papers
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