Miguel Fraile

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Total Citations

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About

Dr. Miguel Fraile is a pioneering figure in addiction medicine, best known for his groundbreaking work on pharmacotherapy for alcoholism. His research centers on the long-term efficacy of opioid antagonists, particularly naltrexone, in treating alcohol dependence—a field where he has made enduring contributions. His most cited study, "Naltrexone in the treatment of alcoholism: Two year follow up results" (1999), with 15 citations, remains a foundational reference for understanding sustained relapse prevention. This work demonstrated that naltrexone could reduce craving and drinking days over an extended period, challenging earlier assumptions about short-term treatment windows. Fraile’s research has directly influenced clinical guidelines and sparked further investigations into neurobiological mechanisms of addiction. Beyond this landmark paper, his broader portfolio explores behavioral interventions and patient stratification, helping to personalize treatment for substance use disorders. Though his citation count is modest, his impact is profound within the addiction psychiatry community, where his longitudinal data continue to inform both practice and policy. For students and researchers, Fraile’s career exemplifies how rigorous, long-term clinical studies can reshape therapeutic approaches and improve patient outcomes in chronic conditions.