Masahiko Saga

St. Marianna University School of Medicine

Papers

Total Citations

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About

Masahiko Saga is a pioneer in the field of reproductive biology and micromanipulation technology, best known for his groundbreaking work in assisted fertilization. His most cited research, "Subzonal insemination of a single mouse spermatozoon with a personal computer‐controlled micromanipulation system" (1992, 25 citations), introduced an innovative automated approach to sperm injection. By developing a system that paired three-dimensional hydraulic micromanipulators with pulse motor control, Saga enabled precise, computer-assisted placement of a single sperm into the perivitelline space of mouse ova. This work laid critical technical foundations for modern intracytoplasmic sperm injection (ICSI) and automated micromanipulation in embryology. Saga’s contributions have been instrumental in advancing reproductive technologies, offering new possibilities for fertility research and clinical applications. His integration of engineering and biology continues to inspire researchers working at the intersection of automation and cell manipulation.