Martine Zucco
Papers
1
Total Citations
22
H-Index
1
About
Dr. Martine Zucco is a pioneering figure in medicinal chemistry, best known for her innovative work in combinatorial chemistry and the development of therapeutic agents for lysosomal storage disorders. Her research centers on the design and parallel synthesis of N-substituted aminocyclitol libraries, with a particular focus on inhibitors of glucocerebrosidase—a key enzyme implicated in Gaucher disease. In her landmark 2006 study, which has garnered 22 citations, Zucco introduced a solution-phase parallel synthesis methodology employing robotic technology to generate diverse libraries of scyllo- and racemic chiro-aminocyclitol derivatives. By systematically reacting core scaffolds with aldehydes and acyl chlorides, she demonstrated a powerful, high-throughput approach to chemical diversification. This work not only advanced the toolkit for rapid drug discovery but also provided preliminary evaluation of these compounds as glucocerebrosidase inhibitors, laying critical groundwork for future therapeutic development. Dr. Zucco’s contributions exemplify the synergy of synthetic efficiency and biological targeting, making her a notable figure in the quest for treatments for rare genetic diseases.
Research Focus
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Top Papers
- 1