Papers
1
Total Citations
22
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1
About
Gilbert Emeric is a medicinal chemist whose work bridges synthetic methodology and therapeutic discovery, with a particular focus on the development of novel inhibitors for lysosomal storage disorders. His research centers on the design and parallel synthesis of N-substituted aminocyclitol libraries, leveraging combinatorial chemistry and robotic automation to generate structural diversity from scyllo and chiro scaffolds. His most cited work, a 2006 study with 22 citations, exemplifies this approach by introducing chemical diversity through reactions with aldehydes and acyl chlorides, and evaluating the resulting compounds as glucocerebrosidase inhibitors—a key target in Gaucher disease. This contribution not only advanced the toolkit for accessing aminocyclitol derivatives but also provided early leads for therapeutic intervention. Emeric’s work is notable for its integration of efficient solution-phase parallel synthesis with biological screening, demonstrating how automated, high-throughput methods can accelerate the discovery of enzyme modulators. His research continues to impact the field of carbohydrate mimetics and drug discovery for rare diseases.
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