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About

Maria Pasquini is a leading researcher in neurorehabilitation, specializing in post-stroke motor recovery through the integration of robotics, neuromodulation, and plasticity-enhancing strategies. Her work centers on understanding how cortical plasticity can be harnessed to restore motor function after ischemic stroke. Pasquini’s major contributions include demonstrating that combining optogenetic stimulation with motor training significantly improves functional recovery and perilesional cortical activity (28 citations). She also developed an innovative robotic system for adaptive training and function assessment of forelimb retraction in mice (18 citations), advancing translational tools for motor rehabilitation. Notably, her research on combining robotics with enhanced serotonin-driven cortical plasticity (6 citations) and gamma neuromodulation with robotic rehabilitation (2–3 citations) highlights her pioneering efforts to restore parvalbumin interneuron dynamics and gamma band function. Her work using wide-field imaging with red-shifted functional indicators (3 citations) further showcases her technical expertise in monitoring cortical activity during motor tasks. Pasquini’s studies consistently emphasize the restoration of motor-evoked cortical activity as a hallmark of effective rehabilitation therapy. With a growing citation impact, she is shaping the future of stroke rehabilitation by bridging basic neuroscience and clinical applications.