Cristina Spalletti
Neuroscience Institute, National Research Council, Scuola Superiore Sant'Anna
Papers
9
Total Citations
476
H-Index
6
About
Cristina Spalletti is a leading neuroscientist whose work sits at the intersection of stroke recovery, neuroplasticity, and rehabilitation robotics. Her research focuses on understanding how the brain rewires itself after ischemic damage and how to harness that plasticity through targeted, technology-driven interventions. A central contribution of her work is the development and validation of the M-Platform, a robotic system for quantitative assessment and adaptive training of forelimb function in mouse models of stroke. This tool has enabled her to link specific rehabilitative therapies to measurable changes in neural circuitry. Her most cited paper (2017, 243 citations) reviews neuroplastic changes after brain ischemia and their role in spontaneous recovery, establishing a framework for novel rehabilitation strategies. She has also pioneered combination therapies that pair robotic training with interventions such as inactivation of the contralesional hemisphere or enhanced serotonin-driven plasticity, demonstrating that these approaches can restore pre-stroke motor patterns and improve functional outcomes. Her recent work (2024–2025) explores gamma-band neuromodulation to restore parvalbumin interneuron dynamics, opening new avenues for circuit-specific repair. With over 470 cumulative citations, Spalletti’s research bridges fundamental neuroscience and translational neurorehabilitation, offering concrete pathways to improve recovery after stroke.
Research Focus
Key Achievements
Top Papers
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