Marc R. Wilkins

Papers

Total Citations

1,046

H-Index

About

Marc R. Wilkins is a pioneering figure in the field of proteomics, best known for coining the term "proteome" and laying the foundational frameworks for large-scale protein analysis. His key research areas include proteome mapping, protein identification technologies, and the systems biology of minimal organisms. Wilkins made a landmark contribution with his 1995 study on *Mycoplasma genitalium*, the smallest known self-replicating organism, where he produced the first comprehensive protein map of a minimal cell. This work, cited over 940 times, revealed a high proportion of acidic proteins and used amino acid composition to identify 50 gene products, setting a new standard for proteome projects. He further advanced the field by developing automated approaches for high-throughput protein identification, as detailed in his 1998 paper, which addressed the critical need for speed and efficiency in large-scale proteomics. His work has been instrumental in transforming proteomics from a manual, labor-intensive discipline into a high-throughput, data-driven science, enabling researchers to systematically explore the protein landscapes of organisms and driving forward our understanding of cellular function and disease.