Marc Graille
Papers
2
Total Citations
43
H-Index
2
About
Marc Graille is a structural biologist whose work has significantly advanced high-throughput methods for protein structure determination. His research focuses on structural genomics, particularly the development and optimization of crystallization strategies and laboratory information management systems (LIMS) to accelerate the discovery of protein folds. Graille’s major contributions include pioneering open-source solutions like *HalX*, a LIMS designed to streamline data management for small- to large-scale laboratories, enabling efficient tracking of samples and experimental workflows. This tool, cited 28 times, has become a foundational resource for structural biology labs transitioning to automated, high-throughput pipelines. Additionally, his work on crystal-optimization strategies for the South Paris Yeast Structural Genomics Project, cited 15 times, addressed a critical bottleneck in X-ray crystallography by demonstrating that automated nanodrop screening could be effectively standardized, making high-throughput structure determination more accessible. Graille’s achievements lie in bridging the gap between explosive protein sequence data and structural coverage, providing practical, scalable solutions that empower researchers to systematically map the protein-fold universe. His contributions remain vital for labs seeking to integrate automation and data management into structural biology.
Research Focus
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Top Papers
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