Jing-Yan Han

Papers

Total Citations

1,480

H-Index

About

Jing-Yan Han is a pioneering researcher at the intersection of DNA nanotechnology and biomedicine, best known for her groundbreaking work in developing DNA-based nanorobots for targeted cancer therapy. Her most cited paper, "A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo" (2018), has garnered over 1,480 citations, marking a transformative advance in the field. In this study, Han and her team engineered a DNA nanorobot that navigates the bloodstream, recognizes a molecular trigger specific to tumor microenvironments, and delivers a therapeutic payload directly to cancer cells, minimizing off-target effects. This work demonstrated the first in vivo application of a DNA nanorobot for cancer treatment, opening new avenues for precision medicine. Beyond this flagship achievement, Han’s research spans the design of dynamic DNA nanostructures, logic-gated drug delivery systems, and biomolecular computing. Her contributions have been recognized with multiple awards and invitations to speak at international conferences, solidifying her reputation as a leader in DNA nanotechnology. For students and researchers, Han’s work exemplifies how interdisciplinary approaches—merging engineering, biology, and chemistry—can solve complex medical challenges.