Ippei Sakamoto
Papers
1
Total Citations
6
H-Index
1
About
Ippei Sakamoto is a cancer geneticist whose research focuses on the molecular mechanisms driving clear cell renal cell carcinoma (ccRCC), with a particular emphasis on the Von Hippel-Lindau (VHL) tumor suppressor pathway. His most cited work, published in 2022, investigates the complex genomic events underlying multifocal ccRCC, demonstrating how derivative chromosome 3 loss from a t(3;6)(q12;q14) translocation, followed by differential VHL mutations, drives tumor heterogeneity and multifocality. This study, which has garnered 6 citations, provides critical insights into the clonal evolution of kidney cancer and the role of VHL inactivation in tumorigenesis. Sakamoto’s research elucidates how loss of functional pVHL leads to HIFα accumulation, a key step in ccRCC development, and highlights the importance of understanding early genetic events for improved diagnosis and targeted therapies. His work contributes to the growing body of knowledge on tumor suppressor gene mechanisms and cancer genomics, offering valuable perspectives for researchers studying renal cell carcinoma and the VHL/HIF axis.
Research Focus
Key Achievements
Top Papers
- 1