Hugues Ouellet
Papers
1
Total Citations
37
H-Index
1
About
Hugues Ouellet has made significant contributions to the structural and functional understanding of cytochrome P450 enzymes, particularly those from *Mycobacterium tuberculosis*. His research focuses on the biochemistry of these heme-thiolate proteins, exploring their potential as novel drug targets for tuberculosis. Ouellet’s landmark study on the interaction of *M. tuberculosis* CYP130 with heterocyclic arylamines (2009, 37 citations) revealed how this enzyme binds diverse nitrogenous compounds, including antifungal azoles, providing critical insights into the structural basis of inhibition. This work demonstrated that CYP130’s active site flexibility accommodates various ligands, informing rational drug design against persistent TB infections. By characterizing the substrate specificity and inhibition mechanisms of mycobacterial P450s, Ouellet has advanced the pharmacological development of azole-based therapeutics. His findings have been instrumental in bridging structural biology and medicinal chemistry, highlighting the vulnerability of these enzymes to existing antifungal agents. Through detailed crystallographic and spectroscopic analyses, Ouellet has established a foundation for targeting P450s in *M. tuberculosis*, contributing to the broader fight against antimicrobial resistance.
Research Focus
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- 1